MOTS-C: The Powerhouse Peptide

🧬What is MOTS-c?

MOTS-c is a 16-amino acid mitochondrial-derived peptide that regulates cellular energy metabolism through AMPK pathway activation. AMPK pathway activation (defined as Adenosine Monophosphate-Activated Protein Kinase) is basically when cells monitor their own energy status. Once activated, AMPK initiates a metabolic shift, promoting energy generation and halting energy consumption. It influences carbohydrate, fat, and protein metabolism throughout the body. The overall function of MOTS-C is to enhance glucose uptake, fat oxidation, mitochondrial biogenesis, and cellular stress resilience. The result? Enhanced fat burning, improved insulin sensitivity, and greater energy efficiency throughout the body!

🌟 Benefits of MOTS-C

Category	Key Benefits
Metabolic Health	Improves insulin sensitivity, glucose regulation, and metabolic flexibility
Fat Loss	Promotes fat oxidation, reduces adipose inflammation, and prevents diet-induced obesity
Energy & Performance	Enhances endurance, spares glycogen during exercise, and boosts ATP production
Longevity	Activates stress resilience pathways (FoxO), supports mitophagy, and reduces oxidative damage
Muscle Recovery	Improves mitochondrial efficiency and reduces muscle fatigue
Cognitive Function	May protect against neurodegeneration via mitochondrial support

⚠️ Side Effects & Risks

Type	Description
Injection Site Reactions	Redness, swelling, or pain at the injection site (common with subcutaneous peptides)
Metabolic Risks	Potential for hypoglycemia due to excessive AMPK activation, especially in sensitive individuals
Muscle Wasting	High doses may suppress mTOR, leading to muscle atrophy or impaired recovery
Cardiovascular Effects	Some animal studies show elevated blood pressure with prolonged use
Gastrointestinal Issues	Nausea, bloating, or altered bowel habits in some cases
Neurological Impact	Rare reports of dizziness or headaches; long-term effects unknown

💉 Dosing Protocols

There are many different ways to dose MOTS-C and numerous studies have concluded that for the most part their isn’t really a wrong way. As a precaution, you should always start with what you deem a smaller dose to ensure no negative side effects before diving head on into larger and more frequent dosages.

Goal	Dosage	Frequency	Duration
General Use	5–10 mg	1x daily	4–6 weeks
Metabolic Reset	5 mg	Every 5 days	4 doses over 20 days
Performance Boost	10–20 mg	3x/week	4–10 weeks
Longevity Support	10 mg	Weekly	Up to 10 weeks/year
Research Use	0.5–1.0 mg/kg	Variable	As per protocol

Administration: Subcutaneous injection, typically into the abdomen. Reconstitution with bacteriostatic water is required.

One scientific study highlights the promising usage of this peptide, and more information can be read online: HERE